What is MLD (Metachromatic Leukodystrophy)?
MLD is an acronym for Metachromatic Leukodystrophy. MLD is an autosomal recessive genetic disorder and is directly caused by a deficiency of the enzyme Arylsulfatase-A. Without this enzyme sulfatides build up, eventually destroying the myelin sheath of the nervous system. The myelin sheath is a fatty covering that protects nerve fibres. Without it, the nerves in the brain and the peripheral nerves cease to function properly. At the moment the only treatment approved by the NHS is Gene Therapy, but this is not available for all forms of MLD.
THE TYPES OF MLD